The Device Physics of Cellular Logic Gates

Biochemical logic circuits that precisely control gene activity in cells are useful for creating novel living organisms with well-defined purposes and behaviors. An important element in designing and implementing these circuits is matching logic gates such that the couplings produce the correct behavior. In this paper, we report in-vivo experimental results that examine and optimize the steady state behavior of cellular logic gates and genetic circuits synthesized in our lab. The optimized gates have the desired input/output characteristics for constructing robust genetic logic circuits of significant complexity.